A recent study indicates that patients who discontinue blockbuster slimming jabs like Wegovy and Mounjaro may regain reduced body mass far faster than those who halt conventional diet and exercise regimens.
Research printed in a major medical journal points out that while overweight individuals frequently drop a large proportion of their body weight while on the medication, the weight returns at an average rate of nearly a kilo each month upon discontinuation.
"Individuals buying such medications must be informed of the danger of fast rebound weight gain when the treatment ends," warns expert Dr. Susan Jebb.
Such speed of recovery implies a return to starting weight in about a year and a half.
Comparing Treatments
The study, which examined dozens of studies involving thousands of participants, contrasted the outcomes of these new drugs with other pills.
Scientists note that individuals who shed pounds through diet and exercise usually experience a less rapid weight regain—around 0.1 kg a month—after stopping.
Explaining the Fast Regain
Nutrition scientists believe the mode of action of the jabs accounts for the heightened weight return.
The injections mimic a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Artificially providing the hormone concentrations far above than the body's typical production might result in the system to generate a reduced amount of its endogenous GLP-1, and may also diminish responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Stopping of this medication leads to hunger is uncontrolled, making excessive eating a significant risk."
A Lifelong Issue?
Health authorities recommend the injections for people with obesity-related health risks, alongside recommended lifestyle changes.
A number of clinicians say that, considering the high risk of weight regain, the therapy should be considered long-term.
This opinion is reinforced by pharmaceutical companies, who note that the findings "emphasize the chronic nature of excess weight," similar to managing conditions like diabetes.
Patient Experiences
People who have come off the medication report a intense resurgence of appetite.
"I experienced something activating and you become ravenous," recalled a patient.
This difficulty is worsened if individuals have not developed permanent lifestyle or habit changes during treatment.
Widespread Interest
Figures indicate that millions of adults in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Use is more common among women than men.
- The middle-aged age group shows the greatest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Ultimately, experts caution that while the jabs are effective tools for shedding pounds, they are not a permanent cure and long-term success hinges on combined lifestyle management.
